Mayadas, TN, Johnson RC, Rayburn H, Hynes RO, Wagner DD (1993) Leukocyte rolling and extravasation are severely compromised in P-selectin-deficient mice. This process is experimental and the keywords may be updated as the learning algorithm improves.Īsako H, Kurose I, Wolf R, DeFrees S, Zheng Z, Phillips ML, Pauslon JC, Granger DN (1994) Role of HI receptors and P-selectin in histamine-induced leukocyte rolling and adhesion in postcapillary venules. These keywords were added by machine and not by the authors.

Areas of controversy and uncertainty will be highlighted and future directions will be identified. Although nitric oxide, adenosine, prostacyclin and IL-10 have all been suggested to potentially play an important role as inhibitory regulators of adhesion, the focus of this review will be the role of nitric oxide as an anti-adhesive molecule. Although much work has focussed on the multitude of inflammatory mediators that contribute to leukocyte recruitment there is very little information regarding the role of endogenous anti-adhesive molecules that “turn off” the inflammatory response. The key feature and underlying pathogenic factor that contributes to these conditions is the persistent recruitment of leukocytes which are thought to contribute to the vascular and tissue injury.

Inflammation is a normal response to infection and/or cellular and tissue injury, however following ischemia/reperfusion and sepsis, an over-exuberant or inappropriate inflammatory response leads to deleterious consequences to host tissue.

Curran kubes